Mebufotenin
5-MeO-DMT, BPL-003, GH001
2 assets6 European trial records1 deal
- Chemical class
- tryptamine alkaloid
- Mechanism
- Not independently verified. Acquirer release describes the pipeline as rapid-acting neuroplastogens designed to restore synaptic connectivity. Recorded as the company's characterisation, not ours.
Assets
Phase 2b complete
clinicaltrials.govverified 2026-09-15
Phase 2b complete
clinicaltrials.govverified 2026-08-25
European trials
Czechia 2
PHASE2 · COMPLETED
clinicaltrials.govctgov registryverified 2026-08-31
Therapeutic exploratory (Phase II) · Ended
euclinicaltrials.euctis registryverified 2026-08-31
Germany 5
PHASE2 · COMPLETED
clinicaltrials.govctgov registryverified 2026-08-31
PHASE2 · TERMINATED
clinicaltrials.govctgov registryverified 2026-08-31
PHASE2 · COMPLETED
clinicaltrials.govctgov registryverified 2026-09-15
Therapeutic exploratory (Phase II) · Ended
euclinicaltrials.euctis registryverified 2026-08-31
Therapeutic exploratory (Phase II) · Ended
euclinicaltrials.euctis registryverified 2026-08-31
Ireland 2
PHASE2 · COMPLETED
clinicaltrials.govctgov registryverified 2026-08-31
Therapeutic exploratory (Phase II) · Ended
euclinicaltrials.euctis registryverified 2026-08-31
Netherlands 3
PHASE2 · COMPLETED
clinicaltrials.govctgov registryverified 2026-08-31
PHASE2 · TERMINATED
clinicaltrials.govctgov registryverified 2026-08-31
PHASE2 · TERMINATED
clinicaltrials.govctgov registryverified 2026-08-31
Poland 4
PHASE2 · COMPLETED
clinicaltrials.govctgov registryverified 2026-08-31
PHASE2 · COMPLETED
clinicaltrials.govctgov registryverified 2026-09-15
Therapeutic exploratory (Phase II) · Ended
euclinicaltrials.euctis registryverified 2026-08-31
Therapeutic exploratory (Phase II) · Ended
euclinicaltrials.euctis registryverified 2026-08-31
Spain 4
PHASE2 · COMPLETED
clinicaltrials.govctgov registryverified 2026-08-31
PHASE2 · COMPLETED
clinicaltrials.govctgov registryverified 2026-09-15
Therapeutic exploratory (Phase II) · Ended
euclinicaltrials.euctis registryverified 2026-08-31
Therapeutic exploratory (Phase II) · Ended
euclinicaltrials.euctis registryverified 2026-08-31
Deals
acquisition · closed
sec.govsec filingverified 2026-09-25
Our calls
- Issue 14OpenLilly does not name BPL-003, VLS-01 or mebufotenin in its Q3 2026 earnings press release, earnings deck, prepared remarks or Q&A, as published on the day of the release. Our read of whether the acquired compounds are a pipeline priority to Lilly's shareholders.
- Issue 7OpenWithin 12 months of the Lilly/AtaiBeckley deal closing, neither BPL-003 nor VLS-01 will have a registered Phase 3 trial carrying ANY EU-member-state site, AND Lilly will have disclosed no EMA pathway for either drug. Our read of the deal's incentives, not Lilly's stated plan.
- Issue 5OpenAtaiBeckley's BPL-003 Phase 3 program, when it registers, will use an ADJUNCTIVE design (patients stay on a stable SSRI, no antidepressant washout mandated). BPL-003 commits to the adjunctive camp, not the washout camp (Compass/EPIsoDE).
- Issue 3MISSAtaiBeckley will report first BPL-003 Phase 3 patient dosed in Q3 2026 (after 30 June, before 30 September).
- Issue 2HITAtaiBeckley will NOT announce first BPL-003 Phase 3 patient dosed before 30 June 2026. Expects initiation language near the wire; confirmed dosing slips to Q3.