Next issueIssue 23 · Tue 17 Nov 

Assets

BPL-003

Molecule class
mebufotenin benzoate; described by Lilly as a synthetic form of 5-MeO-DMT, administered intranasally
Mechanism
Not independently verified. Acquirer release describes the pipeline as rapid-acting neuroplastogens designed to restore synaptic connectivity. Recorded as the company's characterisation, not ours.
Phase
Phase 2b complete; company stated Phase 3 activities initiated (Q2 2026 10-Q); no Phase 3 record on ClinicalTrials.gov or CTIS as of 2026-11-02. Sweeps 2026-11-02: ClinicalTrials.gov query.intr BPL-003 returns 4 records, max Phase 2; mebufotenin 6, all GH Research, max Phase 2; VLS-01 1, Phase 2. CTIS search BPL-003 returns 1 record (2024-513457-70-00, Ended 2025-06-26). NCT05870540 COMPLETED, record last updated 2026-09-10
Indication
treatment-resistant depression; separate Phase 2 in alcohol use disorder
Sponsor geography
UK
Next catalyst
First Phase 3 patient dosed reported by AtaiBeckley, by 2026-09-30
Partner
Eli Lilly and Company (acquisition closed 2026-09-11)
IP status
Not checked. Recorded as unchecked rather than left blank.

The catalyst above is recorded as inferred, not verified. It is this publication's reading of the company's guidance, not a date the company has published.

clinicaltrials.govregistryverified 2026-11-02

Registered trials

  • NCT05347849ClinicalTrials.gov

    PHASE1 · Pharmacokinetics in Healthy Adults · COMPLETED · United Kingdom

    clinicaltrials.govctgov registryverified 2026-08-31

  • NCT05660642ClinicalTrials.gov

    PHASE2 · Treatment Resistant Depression · RECRUITING · United Kingdom

    clinicaltrials.govctgov registryverified 2026-08-31

  • NCT05674929ClinicalTrials.gov

    PHASE2 · Alcohol Use Disorder · COMPLETED · United Kingdom

    clinicaltrials.govctgov registryverified 2026-08-31

  • NCT05870540ClinicalTrials.gov

    PHASE2 · Treatment Resistant Depression · COMPLETED · Australia, Germany, Poland, Spain, United Kingdom, United States

    clinicaltrials.govctgov registryverified 2026-09-15

  • 2024-513457-70-00CTIS

    Therapeutic exploratory (Phase II) · Treatment-Resistant Depression (TRD) · Ended · Germany, Poland, Spain

    euclinicaltrials.euctis registryverified 2026-08-31

  • NCT05032833ClinicalTrials.gov

    PHASE1 · Pharmacokinetics in Healthy Adults · COMPLETED · United Kingdom

    clinicaltrials.govctgov registryverified 2026-10-13inferred

Last financing

In the briefing

Issues tagged BECKLEY-PSYTECH or ATAIBECKLEY, the owners of this asset.

Record history